Managing Common Side Effects of Semaglutide

A person holding an injection pen for semaglutide

Starting a new medication like semaglutide for weight loss can feel exciting – until the side effects kick in.

Have you found yourself dealing with issues like nausea, fatigue, or appetite changes and wondering if they’re normal?

At Prima Medicine, we know that semaglutide side effects can be frustrating and interfere with your ability to stay consistent. Led by Dr. Chethana Rao, a Washingtonian magazine Top Doc, we support you with the knowledge and care you deserve. 

This blog walks you through the most common symptoms, why they happen, and how to combat them. For more help, contact our providers. We will gladly work with you to promote a successful weight loss journey. 

The Most Common Semaglutide Side Effects

It’s normal to experience mild to moderate symptoms as your body adjusts to semaglutide. Here are the most reported ones:

  • Nausea
  • Constipation or diarrhea
  • Fatigue
  • Loss of appetite
  • Burping or indigestion

These problems usually improve with time, especially when dosage is increased gradually under your doctor’s supervision.

How to Manage Your Symptoms

You don’t have to suffer in silence through the adjustment phase. Try these tips.

For nausea or indigestion:

  • Eat smaller, low-fat meals.
  • Don’t lie down right after eating.
  • Sip ginger or peppermint tea.
  • Stay hydrated, but avoid carbonated drinks.

For fatigue:

  • Make sleep a priority.
  • Try light exercise like walking to boost energy.
  • Don’t skip meals.
  • Choose balanced, protein-rich snacks.

For constipation:

  • Increase your fiber intake slowly.
  • Drink plenty of water.
  • Practice gentle movements like yoga or stretching.

When to Call Your Doctor

If your side effects persist or worsen over time, it’s important to check in with your provider. Don’t ignore severe stomach pain, vision changes, or signs of dehydration (dry mouth, dark urine, fatigue, etc.).

At Prima Medicine, we’ll never rush you. Our team also offers same-day and weekend appointments to make it easier for you to get help when you need it most.

Seek Support on Your Weight Loss Journey

Side effects don’t have to derail your progress. With the right strategies and a compassionate care team, you can feel more confident in your treatment and set yourself up for better, longer-lasting outcomes.

Our team includes Dr. Shannon Ross, a board-certified Family Nurse Practitioner with experience in both Family and Obesity Medicine as well as medical weight loss. She is pursuing her NP certification with the Obesity Medicine Association. We are also proud to offer weight loss care from Dr. Sylvia Luther, who is certified by the American Board of Family Medicine and the American Board of Obesity Medicine, and Breanne Haberman, a board-certified Family Nurse Practitioner who has worked in healthcare for over 15 years, including more than five years in advanced obesity care.

To take control of your health, contact us at Prima Medicine to schedule a consultation. Call (703) 870-3750 today or book online.

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