How Does Tirzepatide Work? The Dual GIP and GLP-1 Mechanism

A cropped shot of a woman on tirzepatide holding her jeans away from her waist

If you’ve been exploring medical weight loss, you’ve likely come across tirzepatide – a powerful new injectable that’s transforming how we manage obesity and type 2 diabetes.

The effectiveness of this medication lies in its unique dual-action approach, which utilizes both the GIP and GLP-1 hormone pathways.

Our providers at Prima Medicine recommend tirzepatide for patients who have had a hard time losing weight on their own and are seeking science-backed, physician-led solutions. We prioritize personalized, patient-first treatment and ensure you understand your options before progressing with any particular therapy. 

Learn more about how tirzepatide works and its benefits below.

Dual-Hormone Cooperation for Powerful Results

Tirzepatide is a once-weekly injection that mimics two naturally occurring hormones: glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1). These hormones aid in blood sugar and appetite regulation.

Here’s how it works:

  • GLP-1 Receptor Agonism: This mechanism slows digestion, reduces appetite, and enhances the release of insulin after meals. It’s the same hormone targeted by other popular weight loss medications, such as semaglutide.
  • GIP Receptor Agonism: GIP helps improve insulin sensitivity and may also influence fat metabolism. When combined with GLP-1, GIP appears to enhance the appetite-suppressing and weight-reducing effects of GLP-1.

Together, these actions promote sustained weight loss, improved glycemic control, and better metabolic regulation.

Why Consider Tirzepatide?

According to a study published in Diabetes, Obesity, and Metabolism, the majority of patients lose at least 5% of their body weight over the course of treatment with tirzepatide. This makes it a promising tool for those struggling with obesity or insulin resistance.

At Prima Medicine, we guide patients through safe, effective medical weight loss options tailored to their individual health profiles. Led by Dr. Chethana Rao, a Washingtonian Top Doc, our team provides compassionate care with a focus on long-term wellness. With same-day and weekend appointments available, we make it easy to start losing weight and make steady progress.

Explore Tirzepatide with Prima Medicine

Are you curious about whether tirzepatide is right for you and your weight loss goals? Contact Prima Medicine today to schedule a consultation at one of our Northern Virginia locations — Fairfax, South Riding, Merrifield, or Tysons. Call us at (703) 870-3750 or book an appointment online.

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